Sirna Therapeutics, Inc. [RNAI] CEO to Ring The NASDAQ Stock Market Opening Bell

Broadcast Studio

When:

Wednesday, April 5th, 2006 at 9:30 a.m. EST

Feed Information:

The opening bell is available from 9:20 a.m. to 9:35 a.m. on uplinkIA-5 C-band/transponder 14. The downlink frequency is 3980 horizontal;audio: 6.2/6.8. The feed can also be found on Waterfront fiber 1623. Ifyou have any questions, please contact Stephanie Lowenthal at(646) 441-5220.

Highlighted Links At MarketSite - Market Opens

Photos:

To obtain a hi-resolution photograph of the Market Open, please go tohttp://www.nasdaq.com/reference/marketsite_events.stm and click on themarket open of your choice.

About Sirna Therapeutics, Inc. [RNAI]:

Sirna Therapeutics is a clinical-stage biotechnology company developingRNAi-based therapies for serious diseases and conditions, includingage-related macular degeneration (AMD), hepatitis B and C, dermatology,asthma, Huntington's disease, diabetes and oncology. Sirna Therapeuticscompleted its Phase 1 clinical trial for Sirna-027 in AMD in 2005 and withits strategic partner, Allergan, Inc., will move Sirna-027 into Phase 2clinical trials in 2006. Sirna has selected a clinical compound forhepatitis C virus, Sirna-034, which the Company plans to bring into Phase 1clinical trials by the end of 2006. Sirna has established an exclusivemulti-year strategic alliance with GlaxoSmithKline for the development ofsiRNA compounds for the treatment of respiratory diseases. Sirna has aleading intellectual property portfolio in RNAi covering over 250 mammaliangene and viral targets and over 175 issued or pending patents coveringother major aspects of RNAi technology. More information on SirnaTherapeutics is available on the Company's web site athttp://www.sirna.com.

Contacts:Rebecca Galler RobisonSenior Director, Corporate StrategySirna Therapeutics, Inc.303-449-6500

NASDAQ MarketSite:Stephanie Lowenthal646.441.5220

SOURCE:  NASDAQ

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